The recent review by Monrad1 presents several issues about secondary vaccine trials. It lays out the case in which a vaccine has been tested through phases I–III and is being deployed. Subsequently, consideration is being given to conducting ‘trials for another vaccine for the pathogen’. Monrad states: ‘In summary, we may say that researchers have strong prima facie reasons not to conduct a secondary vaccine trial.’ Monrad discusses several factors meriting careful consideration about the need for developing and testing more (...) than one vaccine: relative efficacy, length of immunity, adverse reactions, ease of storage and administration, economic and logistical factors. What is not addressed are the ethical duties that exist when there are competing phase III vaccine candidates for COVID-19. We have serious concerns about potential ethical inadequacies about these ongoing trials and …. (shrink)

Larry Laudan has challenged the realist to come up with a program that submits realism to "those stringent empirical demands which the realist himself minimally insists on when appraising scientific theories." This paper shows how the realist can go about taking up Laudan on this challenge; and, in such a way that the realist hypothesis actually ends up being confirmed, by any empirical standards. In other words, it is shown that we can test for convergent realism, just as readily as (...) Laudan can test for a connection between theories that are controlled by the cannons of science and their subsequent reliability. (shrink)

In “A Confutation of Convergent Realism,” Larry Laudan presents the realist with these fascinating challenges:What,then,of realism itself as a ‘scientific’ hypothesis?…If realism has made some novel predictions or been subjected to carefully controlled tests, one does not learn about it from the literature of contemporary realism. (1981, p. 46.)He then goes on to say:No proponent of realism has sought to show that realism satisfies those stringent empirical demands which the realist himself minimally insists on when appraising scientific theories. (1981, p. (...) 46)Not only do I fully endorse what Laudan says in these passages, I think it is time to take him up on these challenges.Laudan’s position has been that scientific progress can be explained without having to appeal to verisimilitude. Instead, we explain the success of a scientific theory in terms of its subjugation to the cannons of experimental controls: those theories that have been put through proper testing during the course of their formulation are the ones that are most likely to be reliable. (1984, pp. 96-101). (shrink)

Antonio Gramsci is one of the major social and political theorists of the 20th century whose work has had an enormous influence on several fields, including educational theory and practice. Gramsci and Education demonstrates the relevance of Antonio Gramsci's thought for contemporary educational debates. The essays are written by scholars located in different parts of the world, a number of whom are well known internationally for their contributions to Gramscian scholarship and/or educational research. The collection deals with a broad range (...) of topics, including schooling, adult education in general, popular education, workers' education, cultural studies, critical pedagogy, multicultural education, and the role of intellectuals in contemporary society. (shrink)

Subthalamic nucleus deep brain stimulation is an established therapy for Parkinson’s disease motor symptoms. The ideal site for implantation within STN, however, remains controversial. While many argue that placement of a DBS lead within the sensorimotor territory of the STN yields better motor outcomes, others report similar effects with leads placed in the associative or motor territory of the STN, while still others assert that placing a DBS lead “anywhere within a 6-mm-diameter cylinder centered at the presumed middle of the (...) STN produces similar clinical efficacy.” These discrepancies likely result from methodological differences including targeting preferences, imaging acquisition and the use of brain atlases that do not account for patient-specific anatomic variability. We present a first-in-kind within-patient demonstration of severe mood side effects and minimal motor improvement in a Parkinson’s disease patient following placement of a DBS lead in the limbic/associative territory of the STN who experienced marked improvement in motor benefit and resolution of mood side effects following repositioning the lead within the STN sensorimotor territory. 7 Tesla magnetic resonance imaging data were used to generate a patient-specific anatomical model of the STN with parcellation into distinct functional territories and computational modeling to assess the relative degree of activation of motor, associative and limbic territories. (shrink)

After revelations of participation by psychiatrists and psychologists in interrogation of prisoners at Guantánamo Bay and Central Intelligence Agency secret detention centers, the American Psychiatric Association and the American Psychological Association adopted Position Statements absolutely prohibiting their members from participating in torture under any and all circumstances, and, to a limited degree, forbidding involvement in interrogations. Some interrogations utilize very aggressive techniques determined to be torture by many nations and organizations throughout the world. This paper explains why psychiatrists and psychologists (...) involved in coercive interrogations violate the Geneva Conventions and the laws of the United States. Whether done with ignorance of professional ethical obligations or not, these psychiatrists and psychologists have crossed an ethical barrier that may best be averted from re-occurring by teaching medical students and residents in all medical specialties about the ethics principles stemming from the 1946–1947 Nuremberg trials and the Geneva Conventions, together with the Ethics Codes of the World Medical Association and the American Medical Association; and, with regard to psychiatric residents and psychological trainees, by the teaching about The Principles of Medical Ethics With Annotations Especially Applicable to Psychiatry and the Ethical Principles of Psychologists and Code of Conduct, respectively. In this way, all physicians and psychologists will clearly understand that they have an absolute moral obligation to "First, do no harm" to the human beings they professionally encounter. (shrink)

As such, this volume represents the transition from one era of social cognition research to the next.

Le son musical est vibration, et dépend des instruments utilisés. Être fidèle aux instruments prévus par le compositeur ne répond pas à un simple souci d’authenticité. Notre écoute de l’œuvre musicale dépend des gestes instrumentaux pratiqués par les musiciens (gestes que nous voyons au concert, ou que nous supposons si la musique est enregistrée). Les gestes proprement musicaux (liés à l’expressivité de la musique) sont fonction des gestes effectifs pratiqués par l’instrumentiste. Chaque instrument dispose ainsi d’un véritable répertoire gestuel, plus (...) important quand le bras est engagé (violon) que lorsque ce sont seulement les doigts (flûte à bec). La technique de jeu de l’instrument, sa capacité à produire tel ou tel type d’ornement, jouent un rôle important dans la création musicale. L’orchestre, enfin, peut être considéré comme une sorte de grand corps discontinu dont joue le chef d’orchestre. (shrink)

Cet essai propose une esquisse de ce en quoi consiste fondamentalement l’appréciation esthétique de la musique, soulignant à la fois pourquoi un tel engagement compte comme esthétique et pourquoi il compte comme appréciation, et mettant en avant le rôle de la perception du geste dans la saisie de l’expressivité musicale. L’analyse est illustrée par une pièce de musique de chambre de Gabriel Fauré. Dans la dernière section, je fais écho à quelques remarques de Roger Scruton sur la connexion entre musique (...) et dance, dont la pertinence est évidente pour l’appréciation de la musique. (shrink)

Psychiatry is rapidly adopting digital phenotyping and artificial intelligence/machine learning tools to study mental illness based on tracking participants’ locations, online activity, phone and text message usage, heart rate, sleep, physical activity, and more. Existing ethical frameworks for return of individual research results (IRRs) are inadequate to guide researchers for when, if, and how to return this unprecedented number of potentially sensitive results about each participant’s real-world behavior. To address this gap, we convened an interdisciplinary expert working group, supported by (...) a National Institute of Mental Health grant. Building on established guidelines and the emerging norm of returning results in participant-centered research, we present a novel framework specific to the ethical, legal, and social implications of returning IRRs in digital phenotyping research. Our framework offers researchers, clinicians, and Institutional Review Boards (IRBs) urgently needed guidance, and the principles developed here in the context of psychiatry will be readily adaptable to other therapeutic areas. (shrink)